Gvoke can interact with several other medications. Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase side effects or make them more severe. Below, we describe medications that can interact with Gvoke.
Before taking Gvoke, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. People who take beta-blocker medications may have temporary increases in their heart rate or blood pressure after using Gvoke.
Beta-blockers are mainly used to treat high blood pressure and certain heart conditions, such as angina and irregular heart rhythms. Beta-blockers are also found in some eye drops for glaucoma increased pressure in your eye. This is a prescription nonsteroidal anti-inflammatory drug NSAID used to relieve inflammation swelling , pain, and fever. Gvoke may not be as effective in raising blood sugar levels in people who take indomethacin. Taking these drugs together may even make hypoglycemia worse.
If you take indomethacin, talk with your doctor about your treatment options for severe hypoglycemia. Warfarin Coumadin, Jantoven is a prescription anticoagulant medication blood thinner used to treat and prevent blood clots. Taking warfarin with Gvoke can raise the amount of warfarin in your body. Too much warfarin can raise your risk of excessive bleeding. This can lead to increased bleeding or bruising.
In some cases, it can even lead to death. If you take warfarin, talk with your doctor about whether Gvoke is right for you. Your doctor may recommend other treatments for severe hypoglycemia. However, you should still check with your doctor or pharmacist before using any of these products while taking Gvoke. If you have any questions about eating certain foods with Gvoke, talk with your doctor. As with all medications, the cost of Gvoke can vary.
The cost you find on GoodRx. Before approving coverage for Gvoke, your insurance company may require you to get prior authorization. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug.
The insurance company will review the prior authorization request and decide if the drug will be covered. If you need financial support to pay for Gvoke, or if you need help understanding your insurance coverage, help is available. Xeris Pharmaceuticals Inc. This program offers cost savings options for Gvoke prefilled syringes.
They may be able to recommend programs through your local pharmacy to help lower the cost of the drug. Generics tend to cost less than brand-name drugs. Glucagon, the active drug in Gvoke, is available as a generic. However, the forms that glucagon is available as are taken differently than Gvoke. Symptoms of severe hypoglycemia include:.
This can help you and your doctor manage your diet and medications to keep your blood sugar level in a healthy range. Ask your doctor what your target blood sugar level is and at what point you need to use Gvoke. Also, talk with your doctor if you experience severe hypoglycemia. They can help you understand what caused it and help you avoid future episodes of hypoglycemia. You or some else should call or your local emergency number if you experience severe hypoglycemia, even when you take Gvoke.
This hormone works with your liver to make glucose sugar quickly available to your body. Gvoke works in two ways:. Gvoke begins to work quickly to raise your blood sugar level. It may take up to 15 minutes for your body to respond to the drug. Animal studies have also not shown any increased risk of harm to a fetus when used during pregnancy.
However, glucagon the active drug in Gvoke is generally thought to be safe to use while breastfeeding. Gvoke raises your blood sugar level , which could make hyperglycemia worse. Gvoke is only used to treat severe hypoglycemia low blood sugar. Eating carbohydrates after using Gvoke helps you avoid having another episode of hypoglycemia once the effects of the drug wear off. Examples of 15 g of fast-acting carbohydrates include:. Talk with your doctor if you experience severe hypoglycemia.
Sometimes people will need more than one dose of Gvoke to raise their blood sugar. However, keep in mind that each Gvoke pen or syringe can only be used one time. If you need another dose of Gvoke, you must use a new pen or syringe. Talk with your doctor about when you should use insulin after taking Gvoke. Before taking Gvoke, talk with your doctor about your health history.
Glucagon should be used to treat hypoglycemia only if the person is unable to eat, or is unconscious or having a seizure. Glucagon is not expected to harm an unborn baby, but quickly treating hypoglycemia would outweigh any risks posed by using glucagon. It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. In an emergency situation it may not be possible to tell your caregivers if you are pregnant or breast-feeding.
Make sure any doctor caring for your pregnancy or your baby knows you have received this medicine. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; fast or slow heartbeat; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of the following skin changes on your face, legs, groin, or genital area:. This is not a complete list of side effects and others may occur.
Call your doctor for medical advice about side effects. Use Glucagon Glucagen exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Hypoglycemia should be treated as quickly as possible. Having low blood sugar for too long can cause seizure, coma, or death. Glucagon is injected under the skin, into a muscle, or into a vein. You will be shown how to use emergency glucagon injections for severe hypoglycemia.
Call your doctor after each time you use a glucagon injection. Throw away any unused mixed medicine. Patients with diabetes should be aware of the symptoms of hypoglycemia low blood sugar.
These symptoms may develop in a very short time and may result from:. Unless corrected, hypoglycemia will lead to unconsciousness, seizures, and possibly death. Early symptoms of hypoglycemia include: anxious feeling, behavior change similar to being drunk, blurred vision, cold sweats, confusion, cool pale skin, difficulty in concentrating, drowsiness, excessive hunger, fast heartbeat, headache, nausea, nervousness, nightmares, restless sleep, shakiness, slurred speech, and unusual tiredness or weakness.
Symptoms of hypoglycemia can differ from person to person. It is important that you learn your own signs of low blood sugar so that you can treat it quickly. It is a good idea also to check your blood sugar to confirm that it is low. You should know what to do if symptoms of low blood sugar occur. Eating or drinking something containing sugar when symptoms of low blood sugar first appear will usually prevent them from getting worse, and will probably make the use of glucagon unnecessary.
Good sources of sugar include glucose tablets or gel, corn syrup, honey, sugar cubes or table sugar dissolved in water , fruit juice, or non-diet soft drinks. If a meal is not scheduled soon 1 hour or less , you should also eat a light snack, such as crackers and cheese or half a sandwich or drink a glass of milk to keep your blood sugar from going down again.
You should not eat hard candy or mints because the sugar will not get into your blood stream quickly enough. You also should not eat foods high in fat such as chocolate because the fat slows down the sugar entering the blood stream. After 10 to 20 minutes, check your blood sugar again to make sure it is not still too low. Tell someone to take you to your doctor or to a hospital right away if the symptoms do not improve after eating or drinking a sweet food. Do not try to drive, use machines, or do anything dangerous until you have eaten a sweet food.
Tell your doctor right away if you have blurred vision, dizziness, nervousness, headache, pounding in the ears, or slow or fast heartbeat. These may be symptoms of high blood pressure. This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and requires immediate medical attention.
Call your doctor right away if you have a rash, itching, trouble breathing, trouble swallowing, any swelling of your hands, face, or mouth, or lightheadedness, dizziness, or fainting while you are receiving this medicine. This medicine may cause serious skin reactions, including necrolytic migratory erythema NME.
Check with your doctor right away if you have blistering, peeling, red skin rash in the face, groin, buttocks, or legs. If severe symptoms, including seizures or unconsciousness occur, the patient with diabetes should not be given anything to eat or drink.
Study selection and data extraction: All abstracts were screened for eligibility, which consisted of studies reporting the effects of GLP-1RA administration on the pharmacokinetics and pharmacodynamics of concurrent oral medications. Data extracted from eligible trials included study and population characteristics; pharmacokinetic parameters including maximum concentration C max , time to maximum concentration t max , and area under the concentration-time curve AUC ; and pharmacodynamic properties.
Data synthesis: Our search identified potentially relevant articles; of those, 11 articles evaluating 15 drug interactions were reviewed.
0コメント